If your network is a bit too chatty and you decide to go without NetBIOS, that is easy to do if you have Windows Server. A click or two will get you there. Fortunately, if you have your DHCP server on Mikrotik, it is not much more difficult.
First we need to create Microsoft Disable NetBIOS Option itself:
/ip dhcp-server option
add code=43 name=microsoft-disable-netbios-option value=0x010400000002
And then we simply assign it to given DHCP network:
/ip dhcp-server network
set 1 dhcp-option=microsoft-disable-netbios-option
To verify, simply use ipconfig on windows computer:
> ipconfig /all
NetBIOS over Tcpip. . . . . . . . : Disabled
PS: Do note that really old client computers (e.g. Windows 2000) will have issues with network browsing.